Patient-derived tumor xenograft (PDX) mouse models are a versatile oncology research platform for studying tumor biology and for testing chemotherapeutic approaches tailored to genomic characteristics of individual patients’ tumors. PDX models are generated and distributed by a diverse group of academic labs, multi-institution consortia and contract research organizations. The distributed nature of PDX repositories and the use of different metadata standards for describing model characteristics presents a significant challenge to identifying PDX models relevant to specific cancer research questions. The Jackson Laboratory (ITCR PI Carol E. Bult) and EMBL-EBI (ITCR PIs Helen Parkinson and Terry Meehan) are addressing these challenges by co-developing PDX Finder, a comprehensive open global catalog of PDX models and their associated datasets.The PDX Finder resource currently contains information for 1985 PDX models of diverse cancers including those from large resources such as the Patient-Derived Models Repository, PDXNet and EurOPDX.
Link to the PDX Finder publication
Publish Date: Monday, December 10, 2018